What are some of the limitations and disadvantages of using design patterns in TypeScript or JavaScript?

One of the limitations and disadvantages of using design patterns in TypeScript or JavaScript is the lack of efficient and native language features to support these patterns. This often leads to the introduction of additional abstractions or workarounds, such as TypeScript decorators, to implement certain patterns. These workarounds can be less ergonomic and less efficient, resulting in increased development complexity and reduced performance. Deepkit's runtime type system overcomes these limitations by providing a seamless integration of design patterns with the language, allowing for more expressive and efficient code.